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Table 5 TEAEs reporting in each treatment group during the initial 8-week treatment Period 1

From: A randomized placebo controlled clinical trial to evaluate the efficacy and safety of minocycline in patients with Angelman syndrome (A-MANECE study)

  Placebo N = 12 Minocyclin 8 week N = 22
TEAEs – n° (%) patients 1 (8.3) 4 (18.8)
Number of TEAEs 1 4
Infection 1  
Constipation
Diarrhea   1
Cutaneous alterations   1
Coloration dental   
Nauseas   1
Edemas
Increase urine concentration   1
Serious adverse events – n° of patients (%) 0 0
TEAEs leading to treatment discontinuation N (%) patients 0 1 (4.5)a
  1. aVertiginous Syndrome.No alterations in laboratory test