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Table 2 Results in the development index of the MP-R Scale at week 8 (primary endpoint) and specific domains of the MP-R Scale

From: A randomized placebo controlled clinical trial to evaluate the efficacy and safety of minocycline in patients with Angelman syndrome (A-MANECE study)

Age equivalents (months)   PLACEBO (Group A)(N = 11) MINOCYCLINE Group B)(N = 21) Absolute mean differences,95% CI
Primary analysis: Absolute mean changes in the DI (age equivalent in months) of the MP-R Scale
Development index Baseline 12·55 (6·53) 12·00 (6·27) 0·545, 95% CI (−4·29–5·38)
Week 8 14·55 (4·90) 13·90 (6·06) 0·641, 95% CI (−3·69–4·97)
Absolute mean change 2·00 (3·28) 1·90 (3·16) 0·095, 95% CI (−2·22–2·53)
Secondary analysis: Specific domains of the MP-R scale
Cognition Baseline 11·55 (6·18) 12·76 (6·89) −1·216, 95% CI (−6·28–3·85)
Week 8 15·09 (5·46) 14·24 (5·89) 0·852, 95% CI (−3·50–5·22)
Absolute mean change 3·54 (4·4) 1·47 (2·22) 2·069, 95% CI (−0·31–4·44)
Fine Motor Baseline 12·18 (5·94) 11·67 (5·78) 0·515, 95% CI (−3·92–4·95)
Week 8 14·82 (4·30) 13·71 (5·77) 1·104, 95% CI (−2·94–5·15)
Absolute mean change 2·63 (4·17) 2·04 (3·93) 0·588, 95% CI (−2·46–3·64)
Visual Motor Coordination Baseline 12·09 (6·42) 11·29 (6·95) 0·805, 95% CI (−4·34–5·95)
Week 8 15·55 (4·59) 16·24 (7·48) - 0·693, 95% CI (−5·75–4·37)
Absolute mean change 3·45 (4·54) 4·95 (6·31) −1·497, 95% CI (− 5·89–2·89)
Gross Motor Scale Baseline 20·64 (7·90) 18·81 (6·83) 1·827, 95% CI (−3·65–7·30)
Week 8 20·64 (5·87) 20·05 (7·50) 0·589, 95% CI (−4·73–5·91)
Absolute mean change 0·00 (7·16) 1·23 (3·20) −1·238, 95% CI (−4·96–2·48)
Socio-emotional Baseline 19·09 (13·59) 18·57 (7·99) 0·519, 95% CI (−7·24–8·27)
Week 8 15·82 (7·54) 17·62 (8·26) -1·801, 95% CI (−7·90–4·30)
Absolute mean change −3·27 (7·48) −0·95 (7·04) −2·320, 95% CI (− 7·98–3·14)
Adaptive Behavior Scale and Self Care Baseline 20·73 (8·69) 20·29 (6·55) 0·442, 95% CI (−5·13–6·01)
Week 8 21·73 (9·64) 21·24 (7·06) 0·489, 95% CI (−5·60–6·58)
Absolute mean change 1·00 (4·66) 0·95 (3·42) 0·047, 95% CI (−2·90–3·00)