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Fig. 2 | Orphanet Journal of Rare Diseases

Fig. 2

From: Can untreated PKU patients escape from intellectual disability? A systematic review

Fig. 2

Schematic picture outlining the hypotheses regarding the possible mechanism (s) underlying the inter-individual differences in brain vulnerability to high plasma Phe concentrations between PKU patients including: 1) a difference in the transport of Phe and other large neutral amino acids across the blood-brain barrier, 2) a difference in the transport of Phe and other large neutral amino acids across membranes of different cell types within the brain, and 3) a difference in the vulnerability of one or more of the intracerebral processes to high brain Phe concentrations

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