Annual severity increment score as a tool for stratifying patients with Niemann-Pick disease type C and for recruitment to clinical trials

Table 2 Spearman’s pairwise correlations between major subdomains of the Niemann-Pick type C clinical score

	Eye movement	Ambulation	Speech	Swallow	Fine motor skills	Cognition	Seizures	Memory
Eye movement	1.000	0.600	0.472	0.598	0.606	0.600	0.051	0.509
Ambulation	0.600	1.000	0.679	0.658	0.891	0.810	0.412	0.704
Speech	0.472	0.679	1.000	0.689	0.727	0.728	0.331	0.551
Swallow	0.598	0.658	0.689	1.000	0.754	0.561	0.230	0.485
Fine motor skills	0.606	0.891	0.727	0.754	1.000	0.786	0.430	0.754
Cognition	0.600	0.810	0.728	0.561	0.786	1.000	0.354	0.724
Seizures	0.051	0.412	0.331	0.230	0.430	0.354	1.000	0.366
Memory	0.509	0.704	0.551	0.485	0.754	0.724	0.366	1.000

ISSN: 1750-1172