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Fig. 7 | Orphanet Journal of Rare Diseases

Fig. 7

From: Annual severity increment score as a tool for stratifying patients with Niemann-Pick disease type C and for recruitment to clinical trials

Fig. 7

The mean of the maximum absolute deviations (MAD) was calculated for each individual in relation to the predicted trajectory, based on a single or average ASIS score relative to actual severity (panel (a) illustrates MAD in a single case). The black arrow shows the point of maximum deviation. The goodness-of-fit criterion, based on MAD, is depicted in the box and whisker plots for all patients (b) and patients with no seizures (c) and patients with seizures panel (d)). The effects of time on MAD determination depicted as box and whisker plots for patients without seizures (e) and with seizures (f). The analysis was performed for repeat measures spanning data over 0–2 years, 2–4 years and 4–6 years. Each patient only contributes once

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