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Fig. 6 | Orphanet Journal of Rare Diseases

Fig. 6

From: Annual severity increment score as a tool for stratifying patients with Niemann-Pick disease type C and for recruitment to clinical trials

Fig. 6

Plots of total severity score minus hearing defined from either a single ASIS score (standardised to the first data point for each patient) or using a mean ASIS score (repeat measures). The four scatterplots represent patients with and without seizures, and with predicted trajectories calculated based on a single ASIS determination at first visit (a) (without seizures) and (c) (with seizures)) or where predicted trajectories are based on the average of all available ASIS scores for each patient (b and d) for patients with and without seizures, respectively. Each patient has been assigned an individual colour and each visit is represented by a data point (multiple points per patient)

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