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Fig. 4 | Orphanet Journal of Rare Diseases

Fig. 4

From: A prospective natural history study of Krabbe disease in a patient cohort with onset between 6 months and 3 years of life

Fig. 4

Developmental progression of children with Krabbe disease from birth to 8 years of age. Age-equivalent scores (i.e., developmental age) are graphed against actual age for (a) cognitive development, (b) adaptive behavior, (c) receptive language, (d) expressive language, (e) gross motor function, and (f) fine motor function to allow comparisons across tests and monitor development over time. The lines and diamonds represent individual patients, with red indicating patients with disease onset ≤12 months and blue indicating patients with onset > 12 months. The shaded gray area represents typical development with the lines representing the mean and approximate 95% interval for typically developing children

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