Skip to main content

Table 3 Participants with plasma Phe ≤120 μmol/L, ≤360 μmol/L, or ≤ 600 μmol/L

From: Long-term safety and efficacy of pegvaliase for the treatment of phenylketonuria in adults: combined phase 2 outcomes through PAL-003 extension study

 

n

Plasma Phe threshold, n (%)

≤120 μmol/L

≤360 μmol/L

≤600 μmol/L

Overalla

80

63 (78.7%)

64 (80.0%)

66 (82.5%)

Extension study

 Week 48

61

20 (32.8%)

28 (45.9%)

35 (57.4%)

 Week 96

49

17 (34.7%)

22 (44.9%)

30 (61.2%)

 Week 144

45

19 (42.4%)

25 (55.6%)

29 (64.4%)

 Week 192

39

13 (33.3%)

17 (43.6%)

23 (58.9%)

 Week 240

22

11 (50.0%)

13 (59.1%)

16 (72.7%)

 Week 264

19

5 (26.3%)

6 (31.6%)

8 (42.1%)

 Overall

68

57 (83.8%)

58 (85.2%)

59 (86.7%)

  1. All data from phase 2 studies are included. Sample size reflects participants with data available at study timepoint; study is ongoing
  2. Phe phenylalanine
  3. aAchievement of thresholds at any time during phase 2 study