Transcriptome level analysis in Rett syndrome using human samples from different tissues

Table 1 Summary of the gene expression evidence for changes in dendritic arborisation and synaptic maturation identified by transcriptomic analyses in human Rett Syndrome tissues

Dendritic Arborisation and Synaptic Maturation
Gene	Expression	Tissue	Gene	Expression	Tissue
FXDY1 ²	↑	FC	SYT5 ¹	↓	FC & PC
EAAT2 ²	↑	FC	VAMP2 ¹	↓	FC & PC
NTRK2 ²	↑	FC	NSF ¹	↓	FC & PC
ANXA6 ¹	↓	FC & PC	NPTX1 ¹	↓	FC & PC
STX1A ¹	↓	FC & PC	PPP3CB ¹	↓	FC & PC
DOC2A ¹	↓	FC & PC	GABRD ¹	↓	FC & PC
SNAP-25 ¹	↓	FC & PC	GRIN2A ¹	↓	FC & PC
14–3-3 β/τ/ζ/ν ¹	↓	FC & PC	CAMK2B ¹	↓	FC & PC
MAP2 ¹	↓	FC & PC	NOEL ¹	↓	FC & PC
MAP1A ¹	↓	FC & PC	NNAT ¹	↓	FC & PC
MAPT ¹	↓	FC & PC	ENO2 ¹	↓	FC & PC
GRIA1 ¹	↓	FC & PC	PCP4 ¹	↓	FC & PC
GRIA2 ¹	↓	FC & PC	INA ¹	↓	FC & PC
GABRB3 ¹	↑	FC & PC	NEFH ¹	↓	FC & PC
GRIN1 ¹	↑	FC& PC	NFATC2 ⁶	↓	WB
GRM1 ¹	↑	FC & PC	NFATC3 ⁶	↓	WB
GRM8 ¹	↑	FC & PC	CRMP1 ³	↑	FC
GABRR1 ¹	↑	FC & PC	DNMI ³	↑	FC
GABRP ¹	↑	FC & PC
SYP ¹	↓	FC & PC
SYN2 ¹	↓	FC & PC
SYNGR1 ¹	↓	FC & PC
SYNGR3 ¹	↓	FC & PC
SYT1 ¹	↓	FC & PC

Colantuoni et al. [23]¹, Deng et al. [24]², Gibson et al. [25]³, Lin et al. [26]⁴, Pecorelli et al. [34]⁵, Colak et al. [14]⁶, Tanaka et al. [47]⁷. FC Frontal Cortex, PC Parietal Cortex TC Temporal Cortex, WB Whole Blood, PBMC Peripheral Blood Lymphmonocytes, RTT-IPS Rett patient derived Induced pluritpotent Stem cells

ISSN: 1750-1172