Fig. 4
From: Encephalopathies with intracranial calcification in children: clinical and genetic characterization
Atypical AGS – Top, brain MRI at 4 years old, (a-d), demonstrate mildly hyperintense T2 signal of the white matter relative to the cortex probably due to delayed myelination; CT show (e) basal ganglia calcification. Bottom, (f-j), brain MRI at 11 years old demonstrate myelination progression and multiple small confluent T2 hyperintensities in the sub-cortical areas mainly in F1. Enlarged perivascular spaces are visible in the brainstem (arrows in i); MRS in j shows lactate (asterisk) in the abnormal frontal white matter