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Table 2 Charlson Comorbidity Indexed Conditions in PAP Syndrome compared to control individuals

From: Prevalence and healthcare burden of pulmonary alveolar proteinosis

Indexed Comorbidity PAP Control p value
Myocardial Infarction 9 (5.5%) 4 (2.4%) 0.157
Congestive Heart Failure 30 (18.3%) 5 (3%) < 0.001
Peripheral Vascular Disease 10 (6.1%) 4 (2.4%) 0.101
Cerebrovascular Disease 15 (9.1%) 4 (2.4%) 0.009
Dementia 0 (0%) 1 (0.6%) 0.317
Chronic Pulmonary Disease 71 (43.3%) 16 (9.8%) < 0.001
Connective Tissue Disease 14 (8.5%) 1 (0.6%) < 0.001
Peptic Ulcer Disease 3 (1.8%) 2 (1.2%) 0.652
Mild Liver Disease 15 (9.1%) 2 (1.2%) 0.001
Diabetes without Complications 36 (22%) 20 (12.2%) 0.019
Diabetes with End-Organ Damage 8 (4.9%) 2 (1.2%) 0.054
Hemiplegia/Paraplegia 1 (0.6%) 0 (0%) 0.317
Renal Disease 16 (9.8%) 2 (1.2%) < 0.001
Non-metastatic Cancer Hematologic Malignancy 15 (9.1%) 6 (3.7%) 0.042
Moderate/Severe Liver Disease 2 (1.2%) 0 (0%) 0.0156
Metastatic Solid Tumour 2 (1.2%) 2 (1.2%) > 0.9999