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Table 2 Charlson Comorbidity Indexed Conditions in PAP Syndrome compared to control individuals

From: Prevalence and healthcare burden of pulmonary alveolar proteinosis

Indexed Comorbidity

PAP

Control

p value

Myocardial Infarction

9 (5.5%)

4 (2.4%)

0.157

Congestive Heart Failure

30 (18.3%)

5 (3%)

< 0.001

Peripheral Vascular Disease

10 (6.1%)

4 (2.4%)

0.101

Cerebrovascular Disease

15 (9.1%)

4 (2.4%)

0.009

Dementia

0 (0%)

1 (0.6%)

0.317

Chronic Pulmonary Disease

71 (43.3%)

16 (9.8%)

< 0.001

Connective Tissue Disease

14 (8.5%)

1 (0.6%)

< 0.001

Peptic Ulcer Disease

3 (1.8%)

2 (1.2%)

0.652

Mild Liver Disease

15 (9.1%)

2 (1.2%)

0.001

Diabetes without Complications

36 (22%)

20 (12.2%)

0.019

Diabetes with End-Organ Damage

8 (4.9%)

2 (1.2%)

0.054

Hemiplegia/Paraplegia

1 (0.6%)

0 (0%)

0.317

Renal Disease

16 (9.8%)

2 (1.2%)

< 0.001

Non-metastatic Cancer Hematologic Malignancy

15 (9.1%)

6 (3.7%)

0.042

Moderate/Severe Liver Disease

2 (1.2%)

0 (0%)

0.0156

Metastatic Solid Tumour

2 (1.2%)

2 (1.2%)

> 0.9999