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Fig. 6 | Orphanet Journal of Rare Diseases

Fig. 6

From: Increased extracellular matrix deposition during chondrogenic differentiation of dental pulp stem cells from individuals with neurofibromatosis type 1: an in vitro 2D and 3D study

Fig. 6

Ultrastructural analysis of control (a, c, e) and NF1 pellets (b, d, f) after chondrogenic differentiation. a-d: Semithin sections stained with toluidine blue. c-d: Intra and extracellular vesicles (green and red arrows, respectively). c: Control culture, vesicles are small and of uniform size. d: NF1 culture, vesicles present heterogeneity of sizes. e-f: V: matrix vesicles; N: nucleus; white arrows: collagen fibers

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172