Fig. 3

Reduction from baseline in NH₃ levels over the first 72 h of treatment *p < 0.05 combination vs NH₃ scavengers alone; **p < 0.01 combination vs NH₃ scavengers alone; ^†p < 0.05 NH₃ scavengers alone vs carglumic acid alone; ^††p < 0.01 NH₃ scavengers alone vs combination; ^‡p < 0.05 carglumic acid alone vs combination; Wilcoxon test. Data were censored at extracorporeal detoxification initiation. Reduction from baseline calculated as 1 minus the ratio of NH₃ level to baseline, multiplied by 100. N represents the number of episodes evaluated at the time of the retrospective data collection. h: hour; NH₃: ammonia