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Table 3 Dementia screening and neurocognitive test parameter scores in patients with NP-C and patients with eAD

From: Distinguishing neurocognitive deficits in adult patients with NP-C from early onset Alzheimer’s dementia

Test n NP-C patients (n = 7) n eAD patients (n = 15) Mean group difference Cohen’s d effect-sizea p-valueb
Mean ± SD Mean ± SD
Dementia screenings
 MMSE 4 27.0 ± 2.16 13 21.9 ± 1.9 5.1 2.5 p = 0.010
 FAB 5 14.4 ± 3.3 5 11.8 ± 3.3 2.6 0.8 p = 0.245
Neurocognitive test parameters
 RAVLT1 (verbal span) 7 7.0 ± 3.1 15 3.3 ± 1.6 3.7 1.5 p = 0.018
 RAVLT5 (verbal learning) 7 12.9 ± 3.1 15 6.7 ± 2.7 5.6 1.9 p = 0.002
 RAVLT1–5 (total learning) 7 51.0 ± 14.6 15 28.6 ± 8.7 22.4 1.9 p = 0.006
 RAVLT6 (recall after interference) 7 10.1 ± 4.4 15 3.3 ± 2.5 6.9 1.9 p = 0.005
 RAVLT5–6 (forgetting after interference) 7 2.1 ± 1.8 15 3.5 ± 1.9 −1.3 − 0.7 p = 0.141
 RAVLT7 (delayed verbal recall) 7 10.7 ± 3.5 15 1.9 ± 2.1 8.8 3.0 p < 0.001
 RAVLT5–7 (forgetting after delay) 7 1.6 ± 1.1 15 4.8 ± 2.1 −3.2 −1.9 p < 0.001
 RAVLT8 (recognition) 7 13.7 ± 1.9 14 11.3 ± 3.9 2.4 0.5 p = 0.058
 RCFT copy (visuoconstructional ability) 5 29.8 ± 4.1 13 20.7 ± 12.9 9.1 0.9 p = 0.038
 RCFT time to copy (seconds) 5 233.4 ± 95.9 8 306.5 ± 123.5 − 73.1 −0.7 p = 0.259
 RCFT recall (visual memory) 5 12.3 ± 8.0 13 4.8 ± 4.8 7.5 1.1 p = 0.107
 TMT-A (processing speed; seconds) 7 61.6 ± 40.7 14 93.1 ± 81.5 −31.5 −0.3 p = 0.252
 TMT-B (set shifting; seconds) 7 119.0 ± 54.4 10 226.7 ± 101.9 − 107.7 −1.3 p = 0.017
 RWT word fluency (1 min animals) 7 17.3 ± 5.1 13 14.8 ± 5.4 2.4 0.5 p = 0.335
 RWT word fluency (1 min letter S) 7 8.4 ± 3.1 14 11.4 ± 7.8 −3.0 −0.5 p = 0.225
 WMS digit span (forwards) 6 7.0 ± 2.4 14 5.9 ± 1.4 1.1 0.6 p = 0.353
 WMS digit span (backwards) 6 5.7 ± 1.5 14 3.8 ± 1.9 1.9 1.1 p = 0.037
  1. aEffect sizes calculated according to methodology for Cohen’s d statistic for paired t-tests; bp-values specified based on the Welch t-test, unless otherwise specified; p-values based on the Mann-Whitney test; For TMT-A, TMT-B, RCFT time to copy, RAVLT5–6, and RAVLT5–7 subscales, lower scores indicate better performance. Higher raw scores signify better performance for all other neurocognitive test parameters. For dementia screening scores, higher scores represent less impairment on the MMSE and the FAB. FAB Frontal Assessment Battery, MMSE Mini-Mental Status Evaluation, RAVLT Rey Auditory Verbal Learning Test, RCFT Rey Complex Figure Test and Recognition Trial, RWT Regensburger verbal fluency test, TMT Trail-Making Tests A and B, WMS Wechsler Memory Scales