Food as a trigger for abdominal angioedema attacks in patients with hereditary angioedema

Steiner, Urs C.; Kölliker, Lea; Weber-Chrysochoou, Christina; Schmid-Grendelmeier, Peter; Probst, Elsbeth; Wuillemin, Walter A.; Helbling, Arthur

doi:10.1186/s13023-018-0832-4

Orphanet Journal of Rare Diseases

Table 2 Self reported hypersensitivity- and intolerance reactions associated with angioedema (AE) in atopic and non atopic subjects

From: Food as a trigger for abdominal angioedema attacks in patients with hereditary angioedema

Patients	Self reported hypersensitivity/intolerance				SPT		Phadiatop Sx1, fx5; sIgE; (CAP class 1–6)			Localisation of AE	AE induced by
Patients	Inhalation allergens	Food	Drug	Bee−/wasp-stings	Aeroallergns^a	Food^b/drug	Aeroallergens	Food allergens	Bee−/wasp allergens
Atopic, associated with AE (n = 4)
Female	trees, grass, hdm, cat	tomato, green salad			positive for: grass, ash, cat	all negative	positive for: grass (4), birch (1), rye (3), cat dander (2)	negative for fx5, tomato,	nd	abdomen	food
Female	trees, grass	fish, citrus fruits			positive for: grass, birch	all negative	positive for: grass (1), rye (1)	negative for: fx5	nd	abdomen	food
Female	hdm	apple, onion, garlic, cheese, chili		bee- and wasp sting	positive for: hdm	all negative	positive for: hdm (1)	negative for: fx5, onion, apple, chili	negative for: rApim1/10, rVes v5	abdomen	food Bee−/wasp sting
Female	trees, grass, hdm, cat	kiwi,onion, chili, fondue		bee and wasp sting	positive for: birch, ash, grass, hdm	all negative	positive for: grass (3), hdm (3)	negative for: fx 5, onion, kiwi, chili	negative for: rApim1/10, rVes v5	abdomen	food Bee−/wasp sting
Non atopic associated with AE (n = 9)
Female	yes, ns	strawberry, chamomile, pineapple			negative	negative	Sx1 negative	negative for: fx5, chamomile, strawberry, pineapple	nd	abdomen	food
Female		garlic, shrimps, milk			negative	negative	Sx1 negative	negative for: fx5, shrimp, garlic	nd	abdomen	food
Female	grass	milk, bread			negative	negative	Sx1 negative	negative for: fx5, anti tg-IgA	nd	abdomen	food
Female		cheese, apple, banana, garlic, onion, leek			negative	negative	nd	nd	nd	abdomen	food
Female	grass, trees, hdm	walnut, pineapple, chicken	ASS		negative	negative for food allergens, ASS	Sx1 negative	negative for: fx5, chicken, pine apple, walnut	nd	ASS: mouth, eyelid food: abdomen	drugs food
Female	yes, ns	pineapple, peanut, apple, orange, strawberry			negative	negative	Sx1 negative	negative for: fx 5, apple, strawberry, orange, pine apple	nd	abdomen face extremities	food
Male		alcohol, milk			negative	negative	Sx1 negative	fx 5 negative	nd	alcohol: extremities, genitals, abdomen milk: abdomen	food
Male		fish			negative	negative	Sx1 negative	fx5 negative	nd	abdomen	food
Female			Paroxetin®, Pretuval®, Neo-citran®		negative	negative for Paroxetin®, Pretuval®, Neo-citran®	Sx1 negative	nd	nd	face, abdomen	drugs

AE angioedema, SPT skin prick test, hdm house dust mites, ASS acetylsalicylic acid, ns not specified, nd not done
^aSPT: 7 aeroallergens: birch, ash, grass, mugwort, Alternaria alternata, house dust mite and cat dander
^bSPT 14 food allergen extracts: soy, hen’s egg, cow’s milk, celery, apple, codfish, shrimp, peanut, walnut, pepper, curry, rye flour, and wheat flour (aeroallergen extract and food allergen extract by ALK-Abello, Hørsholm, Denmark). Only positive results mentioned
Multitest Sx1: Specific IgE for: timothy grass, birch, cultivated rye, mugwort, dog dander, cat dander, Cladosporium herbarum, D. pteronyssinus
Multitest fx5: Specific IgE for: egg white, cow’s milk, fish (cod), wheat flour, peanut, soy bean
( ): CAP class 1–4 of allergen specific IgE in kU/l: 0: < 0.35; 1: 0.35–0.7; 2: 0.71–3.5; 3: 3.51–17.5; 4: 17.5–50
Anti tg IgA-Ab: anti transglutaminase IgA antibodies (marker for celiac disease)

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ISSN: 1750-1172

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