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Table 2 Self reported hypersensitivity- and intolerance reactions associated with angioedema (AE) in atopic and non atopic subjects

From: Food as a trigger for abdominal angioedema attacks in patients with hereditary angioedema

Patients Self reported hypersensitivity/intolerance SPT Phadiatop Sx1, fx5; sIgE; (CAP class 1–6) Localisation of AE AE induced by
Inhalation allergens Food Drug Bee−/wasp-stings Aeroallergnsa Foodb/drug Aeroallergens Food allergens Bee−/wasp allergens   
Atopic, associated with AE (n = 4)
 Female trees,
grass,
hdm,
cat
tomato,
green salad
   positive for: grass,
ash,
cat
all negative positive for:
grass (4),
birch (1),
rye (3),
cat dander (2)
negative for fx5, tomato, nd abdomen food
 Female trees, grass fish, citrus fruits    positive for: grass,
birch
all negative positive for:
grass (1),
rye (1)
negative for: fx5 nd abdomen food
 Female hdm apple, onion, garlic, cheese, chili   bee- and wasp sting positive for: hdm all negative positive for:
hdm (1)
negative for: fx5, onion, apple, chili negative for:
rApim1/10,
rVes v5
abdomen food
Bee−/wasp sting
 Female trees, grass, hdm, cat kiwi,onion, chili, fondue   bee and wasp sting positive for: birch, ash, grass, hdm all negative positive for:
grass (3),
hdm (3)
negative for: fx 5, onion, kiwi, chili negative for:
rApim1/10,
rVes v5
abdomen food
Bee−/wasp sting
Non atopic associated with AE (n = 9)
 Female yes, ns strawberry, chamomile, pineapple    negative negative Sx1 negative negative for: fx5, chamomile, strawberry, pineapple nd abdomen food
 Female   garlic, shrimps, milk    negative negative Sx1 negative negative for: fx5, shrimp, garlic nd abdomen food
 Female grass milk, bread    negative negative Sx1 negative negative for: fx5, anti tg-IgA nd abdomen food
 Female   cheese, apple, banana, garlic, onion, leek    negative negative nd nd nd abdomen food
 Female grass, trees,
hdm
walnut, pineapple, chicken ASS   negative negative for food allergens,
ASS
Sx1 negative negative for: fx5, chicken, pine apple, walnut nd ASS: mouth, eyelid food: abdomen drugs
food
 Female yes, ns pineapple, peanut, apple, orange, strawberry    negative negative Sx1 negative negative for: fx 5, apple, strawberry, orange, pine apple nd abdomen
face
extremities
food
 Male   alcohol,
milk
   negative negative Sx1 negative fx 5 negative nd alcohol: extremities, genitals, abdomen
milk: abdomen
food
 Male   fish    negative negative Sx1 negative fx5 negative nd abdomen food
 Female    Paroxetin®,
Pretuval®,
Neo-citran®
  negative negative for
Paroxetin®, Pretuval®, Neo-citran®
Sx1 negative nd nd face,
abdomen
drugs
  1. AE angioedema, SPT skin prick test, hdm house dust mites, ASS acetylsalicylic acid, ns not specified, nd not done
  2. aSPT: 7 aeroallergens: birch, ash, grass, mugwort, Alternaria alternata, house dust mite and cat dander
  3. bSPT 14 food allergen extracts: soy, hen’s egg, cow’s milk, celery, apple, codfish, shrimp, peanut, walnut, pepper, curry, rye flour, and wheat flour (aeroallergen extract and food allergen extract by ALK-Abello, Hørsholm, Denmark). Only positive results mentioned
  4. Multitest Sx1: Specific IgE for: timothy grass, birch, cultivated rye, mugwort, dog dander, cat dander, Cladosporium herbarum, D. pteronyssinus
  5. Multitest fx5: Specific IgE for: egg white, cow’s milk, fish (cod), wheat flour, peanut, soy bean
  6. ( ): CAP class 1–4 of allergen specific IgE in kU/l: 0: < 0.35; 1: 0.35–0.7; 2: 0.71–3.5; 3: 3.51–17.5; 4: 17.5–50
  7. Anti tg IgA-Ab: anti transglutaminase IgA antibodies (marker for celiac disease)