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Fig. 6 | Orphanet Journal of Rare Diseases

Fig. 6

From: Neural stem cells for disease modeling and evaluation of therapeutics for infantile (CLN1/PPT1) and late infantile (CLN2/TPP1) neuronal ceroid lipofuscinoses

Fig. 6

Effect of DT on cytoplasmic lipid droplets accumulation in NCL patient NSCs. DT dose-dependently reduced the Nile red staining (a) in NCL NSCs. The quantitative analysis of Nile red fluorescence (b) revealed that clearance effect of lipid droplets ranged from 12.4% in the TPP1E4/E6 NSCs to 34.9% in the TPP1E4/IVS5 NSCs after the treatment with 20 μM δ-tocopherol. The images were taken with 40X objective lens. Data are displayed as mean ± SD. * P < 0.05, *** P < 0.001 compared to the untreated control

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172