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Fig. 5 | Orphanet Journal of Rare Diseases

Fig. 5

From: Neural stem cells for disease modeling and evaluation of therapeutics for infantile (CLN1/PPT1) and late infantile (CLN2/TPP1) neuronal ceroid lipofuscinoses

Fig. 5

The synergistic effect of HPBCD with DT on reduction of enlarged lysosomes in NCL NSCs. a Representative image of a combination of HPBCD and DT on reduction of LysoTracker staining in NCL NSCs compared to DT treatment. b The reduction of enlarged lysosomes ranging from 49% in TPP1E4/E6 NSCs to 78% in TPP1E4/IVS5 NSCs. The images were taken with 40X objective lens. Data are displayed as mean ± SD. * P < 0.05, ** P < 0.01

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172