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Fig. 3 | Orphanet Journal of Rare Diseases

Fig. 3

From: Neural stem cells for disease modeling and evaluation of therapeutics for infantile (CLN1/PPT1) and late infantile (CLN2/TPP1) neuronal ceroid lipofuscinoses

Fig. 3

Effect of DT on reducing enlarged lysosomes in NCL patient NSCs. DT dose-dependently reduced the LysoTracker staining (a) in NCL NSCs. The quantitative analysis of LysoTracker fluorescence (b) revealed that clearance of enlarged lysosomes ranged from 22.8% in the TPP1E4/E6 NSCs to 33.8% in the PPT1E8/E1 NSCs after the treatment with 20 μM DT. The images were taken with 40X objective lens. Data are displayed as mean ± SD. * P < 0.05, ** P < 0.01, *** P < 0.001

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172