Fig. 2

Scatterplot showing the negative correlation between change (Δ) in lumbar spine BMD z-score with bisphosphonate treatment in relation to the age at which treatment was started (17 courses of treatment in 15 individuals). Pearson correlation coefficient − 0.624 (p = 0.01). The new cases (from Table 1) are shown by green circles and the cases previously described in the literature (Table 2) are shown by red squares. The light blue triangle indicates the response in the patient described by Adami et al. [17] who was treated with denosumab for 2 years; the dark blue triangle the patient described by McKiernan [18] who was treated with both pamidronate and teriparatide for two years