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Table 6 Associations between ARM and maternal use of painkiller

From: Maternal drug use and the risk of anorectal malformations: systematic review and meta-analysis

 

Maternal use of painkiller

 

Ref.

First author, year

Exposure

ORcrude [95% CI]

ORadj [95% CI]

Adjustment/matching factors

[58]

Hernandez, 2012

Aspirin

1.3 [0.79, 2.03]

–

–

Ibuprofen

Naproxen

1.1 [0.89, 1.42]

–

 

1.3 [0.84, 2.01]

–

 

[60]

van Gelder, 2011

Non-steroidal anti-inflammatory drugs

1.4 [0.2, 10.7]

–

–

[71]

Czeizel, 2000

Acetylsalicylic acid

–

2.3 [0.9, 5.6]b

Adjusted for maternal age, birth order, acute and chronic maternal disorders and other drug use

 

1.2 [0.7, 2.8]c

 

1.3 [0.5, 3.9]d

[79]

Heinonen, 1977

Aspirina

–

–

–

  1. aThe prevalence per 10,000 live births was 8.75
  2. bA population control group, including maternal self-reported and medically documented drug use
  3. cMedically documented drug use
  4. dPatient control group
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172