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Table 4 Associations between ARM and maternal use of thyroid medication

From: Maternal drug use and the risk of anorectal malformations: systematic review and meta-analysis

 

Maternal use of thyroid medication

 

Ref.

First author, year

Exposure

ORcrude [95% CI]

ORadj [95% CI]

Adjustment/matching factors

[53]

Zwink and Choinitzki, 2015

Thyroid hormone supplementations

1.0 [0.25, 3.74]b

–

–

0.4 [0.10, 1.54]c

  

[75]

Källén and Wikner, 2014

Thyroxin

1.9 [1.00, 1.85]a

–

–

[61]

Browne, 2009

Anti-thyroid medication

8.6 [1.7, 40.2]

–

–

  1. aRisk Ratio (RR)
  2. bCompared to patients with isolated esophageal atresia with or without tracheoesophageal fistula
  3. cCompared to patients with the combined phenotype of esophageal atresia with or without tracheoesophageal fistula and anorectal malformation
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172