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Table 1 Characteristics of the 13 cases inherited ichthyosis treated by alitretinoin

From: Alitretinoin reduces erythema in inherited ichthyosis

Patients Gender Age at start of study Mutated gene Form of II Acitretin treatment before starting AL Reasons for introducing AL Maximum dosage of AL (mg/day) AL duration
(months)
Side effects of AL Treatment change for due to side effects Causes of AL withdrawal Monitoring
1 M 24 ICTHYN LI Yes AC IE 30 36 Moderate headache RD SE
IE at 10 mg/day
Lipid, liver
2 F 33 CYP4F22 LI Yes Desire for pregnancy 10 1 Lipid, liver, β-HCG
3 F 32 ICTHYN LI Yes Desire for pregnancy 30 12 Moderate headache RD SE
IE at 10 mg/day
Lipid, liver, β-HCG
4 F 34 ICTHYN LI Yes Desire for pregnancy 30 36 Lipid, liver, β-HCG
5 F 36 ICTHYN LI Yes Desire for pregnancy 30 24 Lipid, liver, β-HCG
6 F 28 SPINK5 NS No Desire for pregnancy 30 6 Benign intracranial hypertension S SE Lipid, liver, β-HCG
7 M 12 ABCA12 CIE Yes AC SE (mucous dryness) 10 18 Lipid, liver, β-HCG
8 M 38 Not identified CIE Yes AC SE (myalgia) 30 12 Lipid, liver, β-HCG
9 F 35 ABCA12 CIE No Desire for pregnancy 30 24 Moderate headache Lipid, liver, β-HCG
10 F 30 POMP KLICK Yes Desire for pregnancy 10 16 Lipid, liver, β-HCG,TSH,T4 X-rays
11 F 25 TGM1 LI Yes Desire for pregnancy
AC IE
30 15 Myalgia Lipid, liver, β-HCG,TSH,T4 X-rays
12 F 23 ongoing LI Yes Desire for pregnancy
AC IE
20 2 Severe headache
Mucous oral dryness
Lipid, liver, β-HCG,TSH,T4,X-rays
13 F 28 GJB3 EK Yes Desire for pregnancy 30 2 Mucous oral dryness Lipid, liver, β-HCG,TSH
  1. AL alitretinoin, AC acitretin, CIE congenital ichthyosiform erythroderma, EK erythrokeratoderma, IE insufficient efficacy, KLICK keratosis linearis ichthyosis congenital keratoderma, LI lamellar ichthyosis, M months, NS Netherton syndrome, RD reduced dosage, S stopped treatment, SE side-effects, Y years