Table 1 Characteristics of the 13 cases inherited ichthyosis treated by alitretinoin
Patients | Gender | Age at start of study | Mutated gene | Form of II | Acitretin treatment before starting AL | Reasons for introducing AL | Maximum dosage of AL (mg/day) | AL duration (months) | Side effects of AL | Treatment change | Causes of AL withdrawal | Monitoring |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | M | 24 | ICTHYN | LI | Yes | AC IE | 30 | 36 | Moderate headache | RD | SE IE at 10 mg/day | Lipid, liver |
2 | F | 33 | CYP4F22 | LI | Yes | Desire for pregnancy | 10 | 1 | – | – | – | Lipid, liver, β-HCG |
3 | F | 32 | ICTHYN | LI | Yes | Desire for pregnancy | 30 | 12 | Moderate headache | RD | SE IE at 10 mg/day | Lipid, liver, β-HCG |
4 | F | 34 | ICTHYN | LI | Yes | Desire for pregnancy | 30 | 36 | – | – | – | Lipid, liver, β-HCG |
5 | F | 36 | ICTHYN | LI | Yes | Desire for pregnancy | 30 | 24 | – | – | – | Lipid, liver, β-HCG |
6 | F | 28 | SPINK5 | NS | No | Desire for pregnancy | 30 | 6 | Benign intracranial hypertension | S | SE | Lipid, liver, β-HCG |
7 | M | 12 | ABCA12 | CIE | Yes | AC SE (mucous dryness) | 10 | 18 | – | – | – | Lipid, liver, β-HCG |
8 | M | 38 | Not identified | CIE | Yes | AC SE (myalgia) | 30 | 12 | – | – | – | Lipid, liver, β-HCG |
9 | F | 35 | ABCA12 | CIE | No | Desire for pregnancy | 30 | 24 | Moderate headache | – | – | Lipid, liver, β-HCG |
10 | F | 30 | POMP | KLICK | Yes | Desire for pregnancy | 10 | 16 | – | – | – | Lipid, liver, β-HCG,TSH,T4 X-rays |
11 | F | 25 | TGM1 | LI | Yes | Desire for pregnancy AC IE | 30 | 15 | Myalgia | – | – | Lipid, liver, β-HCG,TSH,T4 X-rays |
12 | F | 23 | ongoing | LI | Yes | Desire for pregnancy AC IE | 20 | 2 | Severe headache Mucous oral dryness | – | – | Lipid, liver, β-HCG,TSH,T4,X-rays |
13 | F | 28 | GJB3 | EK | Yes | Desire for pregnancy | 30 | 2 | Mucous oral dryness | – | – | Lipid, liver, β-HCG,TSH |