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Table 3 Pulmonary Structural and Functional Characteristics of Patients with Lymphangioleiomyomatosis

From: Assessing the outcomes of everolimus on renal angiomyolipoma associated with tuberous sclerosis complex in China: a two years trial

Value Baseline
(n = 6)
12 months
(n = 6)
24 months
(n = 5)
Change from Baseline
12 months (n = 6) 24 months (n = 5)
FEV1
 Least-square mean — liters 1.59 ± 0.41 1.87 ± 0.47 1.65 ± 0.45 0.28 ± 0.08 (P<0.001) 0.13 ± 0.05 (P = 0.004)
 Percent of predicted value 58.51 ± 11.09 65.32 ± 12.32 59.89 ± 11.58 6.81 ± 2.28 (P<0.001) 3.46 ± 1.57 (P = 0.008)
FVC
 Least-square mean — liters 2.77 ± 0.56 3.20 ± 0.68 2.95 ± 0.66 0.43 ± 0.17 (P = 0.002) 0.27 ± 0.14 (P = 0.013)
Percent of predicted value 79.90 ± 12.68 87.16 ± 12.63 84.36 ± 13.71 7.26 ± 2.16 (P<0.001) 6.39 ± 1.36 (P<0.001)
Total lung capacity
 Least-square mean — liters 5.16 ± 0.51 5.18 ± 0.44 5.14 ± 0.49 0.03 ± 0.12 (P = 0.62) 0.04 ± 0.10 (P = 0.43)
 Percent of predicted value 99.21 ± 7.01 99.70 ± 7.28 97.75 ± 7.24 0.49 ± 1.47 (P = 0.45) −0.22 ± 0.78 (P = 0.57)
Residual volume
 Least-square mean — liters 2.39 ± 0.10 1.98 ± 0.31 2.11 ± 0.29 −0.41 ± 0.24 (P = 0.009) −0.31 ± 0.23 (P = 0.036)
 Percent of predicted value 124.56 ± 10.04 104.23 ± 8.85 112.30 ± 5.41 −20.32 ± 1.62 (P<0.001) −15.79 ± 2.38 (P<0.001)
DLco
 Least-square mean — ml/mmHg/min 12.93 ± 2.42 13.00 ± 2.41 12.59 ± 2.39 0.07 ± 0.46 (P = 0.71) −0.21 ± 0.55 (P = 0.43)
 Percent of predicted value 53.40 ± 9.29 53.60 ± 8.70 54.27 ± 9.56 0.19 ± 1.39 (P = 0.74) 1.68 ± 2.11 (P = 0.15)
  1. Data are listed for 6 patients with lymphangioleiomyomatosis who completed the 12-month study visit. Data for the 24-month study visit were available for 5 of these 6 patients; 1 patient had withdrawn during the second year. Changes from baseline were not significant unless otherwise indicated. DLco denotes diffusing capacity of the lung for carbon monoxide, FEV1 forced expiratory volume in 1 s, FVC forced vital capacity