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Table 4 Adverse events in patients with sirolimusa

From: Functional improvements in patients with lymphangioleiomyomatosis after sirolimus: an observational study

Adverse events

Number of patients

Percentage (%)

Mouth ulcers

43

43.9

Menstrual abnormality

26

26.5

Hyperlipidemia

15

15.3

Acneiform rash

15

15.3

Diarrhea

2

2.0

Fever

2

2.0

Peripheral edema

2

2.0

Gingival hyperplasia

2

2.0

Infections

1

1.0

Hypertension

1

1.0

Non-productive cough

1

1.0

Nasal allergy

1

1.0

Low back pain

1

1.0

Chest pain

1

1.0

Alopecia

1

1.0

Toothache

1

1.0

Arthralgia (finger)

1

1.0

Dizziness

1

1.0

Palpitation

1

1.0

Elevated alanine aminotransferase

1

1.0

  1. aThree patients stopped sirolimus because of severe adverse effects, which were elevated liver alanine aminotransferase, lung infection and fever. All of them initiated the therapy again after 2 to 6 months and were free of severe adverse events
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172