Fig. 1

Distribution of symptom frequency and abundance in rare cardiac diseases. a Symptom abundance across all diseases displayed as percentage of patients per disease showing a specific symptom (grouped in 10% bins). For instance, 120 annotated symptoms were found in 20–30% of patients affected by a disease. b Frequency of symptom occurrence listed in databases and textual information from the literature, mapped to one of the four categories ‘Rare’ (< 7.5%), ‘Occasional’ (7.5%–32%), ‘Frequent’ (33–89%) and ‘Very frequent’ (≥90%)