Molecular structure

Biologic, n (%)

11 (78.6)

17 (37.0)

OR = 6.06 (1.25 to 38.58)

0.012

Small molecule, n (%)

3 (21.4)

29 (63.0)
  
Missing data, n (%)

0 (0)

0 (0)
  
Number of clinical studies considered, median (range)

3 (3)

2 (13)

Median difference = 0 (0 to 1)

0.305

Missing data, n (%)

1 (7.1)

1 (2.2)
  
Level of evidence considered

At least one double blinded RCT, n (%)

8 (57.1)

42 (91.3)

OR = 0.13 (0.02 to 0.70)

0.007

At least one open label RCT, n (%)

0 (0)

3 (6.5)
  
At least one nonrandomized uncontrolled trial, n (%)

6 (42.9)

1 (2.2)
  
Missing data, n (%)

0 (0)

0 (0)
  
Size of largest study, median, n of patients (range)

59 (156)

167 (1134)

Median difference = −108 (−234 to −50)

0.0001

Missing data, n (%)

0 (0)

5 (10.9)
  
Clinical study comparator

No control, n (%)

5 (35.7)

1 (2.2)

OR = 23.11 (2.23 to 1207.19)

0.0019

Historical control, n (%)

1 (7.1)

0 (0)
  
placebo, n (%)

7 (50.0)

36 (78.3)
  
Active control, n (%)

1 (7.1)

9 (19.6)
  
Missing data, n (%)

0 (0)

0 (0)
  
Annual treatment cost per patient, median (range)

CAN$330,395 (CAN$934,000)

CAN$52,596 (CAN$429,858.5)

Median difference = CAN$243,787.75 (83,396 to 329,050)

P < 0.0001

Missing data, n (%)

1 (7.1)

17 (37.0)
  
Incremental cost per quality adjusted lifeyear, median (range)

CAN$2,680,000 (CAN$560,000)

CAN$ 165,923.5 (CAN$4,574,241)

NA

NA

Missing data, n (%)

12 (85.7)

24 (52.2)
  
Recommendation

Positive recommendation, n (%)

5 (35.7)

33 (71.7)

OR = 0.22 (0.05 to 0.91)

0.025

Negative recommendation, n (%)

9 (64.3)

13 (28.3)
  
Missing data, n (%)

0 (0)

0 (0)
  