Fig. 2From: Characteristics of drugs for ultra-rare diseases versus drugs for other rare diseases in HTA submissions made to the CADTH CDRTime series of the annual number of DRD submission made to CDR over 12 years (for the period 2004 through 2016). a Number of annual submission for the entire period. b Illustration of the change in the number of submissions at the beginning 3 years of the period versus the last 3 yearsBack to article page