Table 4 Odds ratios of major congenital anomalies among NF1 children compared to matched controls
From: Congenital anomalies in neurofibromatosis 1: a retrospective register-based total population study
Anomaly (ICD-10 code) | NF1 (n) | NF1 (1/1000) | Controls (n) | Controls (1/1000) | OR, unadjusted (95% CI) | OR, adjusted (95% CI) | P, unadjusted | P, adjusted |
|---|---|---|---|---|---|---|---|---|
Nervous system (Q00-Q07) | 0 | 0 | 3 | 0.7 | NA | NA | NA | NA |
Eye, ear, face and neck (Q10-Q18) | 3 | 6.8 | 7 | 1.5 | 4.43 (1.12–17.57) | 4.66 (1.42–15.31) | .035 | .011 |
Circulatory sytem (Q20-Q28) | 9 | 20.3 | 25 | 5.5 | 3.74 (1.74–8.04) | 3.35 (1.64–6.83) | <.001 | <.001 |
Respiratory system (Q30-Q34) | 0 | 0 | 0 | 0 | NA | NA | NA | NA |
Cleft lip and cleft palate (Q35-Q37) | 0 | 0 | 11 | 2.4 | NA | NA | NA | NA |
Other digestive system (Q38-Q45) | 1 | 2.3 | 4 | 0.9 | 2.92 (0.33–25.78) | NA | .335 | NA |
Genital organs (Q50-Q56) | 0 | 0 | 1 | 0.2 | NA | NA | NA | NA |
Urinary system (Q60-Q64) | 4 | 9.0 | 11 | 2.4 | 4.27 (1.36–13.37) | 4.26 (1.36–13.35) | .013 | .013 |
Musculoskeletal system (Q65-Q79) | 6 | 13.5 | 22 | 4.8 | 2.83 (1.12–7.11) | 2.77 (1.09–7.02) | .028 | .032 |
Other (Q80-Q89) | 1 | 2.3 | 3 | 0.7 | 3.89 (0.41–36.92) | 3.88 (0.41–36.90) | .237 | .238 |
Chromosomal (Q90-Q99) | 0 | 0 | 0 | 0 | NA | NA | NA | NA |