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Table 5 Search Strategy for Identifying Peer Reviewed Literature on Rare Disease Methods and Infrastructure

From: An overview of the impact of rare disease characteristics on research methodology

Search String

Number of Articles

Date Performed

“Rare Diseases”[Mesh] AND (“clinical trials as topic”[Mesh] OR “research design”[Mesh]) AND ((“2003/01/01”[PDAT]: “3000/12/31”[PDAT]) AND “humans”[MeSH Terms] AND English[lang])

191

1/2016

(“method”[ti] OR “methods”[ti] OR “methodology”[ti] OR “methodologies”[ti] OR “design”[ti] OR “designs”[ti]) AND (“rare diseases”[tw] OR “rare disease”[tw] OR “rare disorders”[tw] OR “rare disorder”[tw] OR “rare conditions”[tw] OR “rare condition”[tw] OR “orphan disease”[tw] OR “orphan diseases”[tw]) AND ((“2003/01/01”[PDAT]: “3000/12/31”[PDAT]) AND English[lang])

121

3/2016