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Table 3 Univariable and multivariable findings for relationships between treatment, BMI and other secondary behavioural outcomes (n = 12)

From: Environmental enrichment intervention for Rett syndrome: an individually randomised stepped wedge trial

Outcomes

Univariable model

Multivariable model

Coefficient (95%CI)

P value

Coefficient (95%CI)

P value

BMI

 Treatment after 2 months

−0.5 (−1, 0.0)

0.042

−0.6 (−1.2, −0.1)

0.026

 Treatment after 4 months

−0.4 (−1.0, 0.2)

0.157

−0.6 (−1.3, 0.1)

0.096

 Treatment after 6 months

0.0 (−0.6, 0.6)

0.938

−0.3 (−1.2, 0.6)

0.49

 Age (years)

−0.3 (−0.9, 0.3)

0.333

−0.3 (−1.1, 0.5)

0.519

 Age at regression (months)

  

0.0 (−0.2, 0.2)

0.707

 Gross motor assessment score (time-varying)

  

0.0 (0.0, 0.1)

0.307

Sleep Disturbance Scale for Children - DIMS subscale

 Treatment after 2 months

0.4 (−1.8, 2.6)

0.73

0.2 (−2.1, 2.4)

0.892

 Treatment after 4 months

0.3 (−2.1, 2.7)

0.81

0.1 (−2.4, 2.6)

0.961

 Treatment after 6 months

0.1 (−2.4, 2.6)

0.93

0 (−2.8, 2.8)

0.998

 Age (years)

−2.6 (−4.7, −0.6)

0.01

−2.2 (−4.8, 0.3)

0.082

 Age at regression (months)

  

−0.1 (−0.7, 0.4)

0.6

 Sleep hygiene score

  

−0.1 (−0.3, 0.2)

0.567

Rett Syndrome Behaviour Questionnaire – Mood subscale

 Treatment after 2 months

−0.1 (−1.8, 1.6)

0.921

−0.2 (−2.0, 1.5)

0.804

 Treatment after 4 months

−0.2 (−2.0, 1.7)

0.874

−0.4 (−2.3, 1.5)

0.691

 Treatment after 6 months

1 (−0.9, 2.9)

0.31

0.7 (−1.3, 2.7)

0.496

 Age (years)

−0.8 (−2.1, 0.6)

0.275

−0.2 (−1.7, 1.4)

0.789

 Age at regression (months)

  

−0.2 (−0.5, 0.2)

0.316