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Table 2 Univariable and multivariable models showing relationships between intervention, Rett Syndrome Gross Motor Scale (RSGMS) scores (n = 12) and blood brain derived neurotrophic factor (BDNF) levels (n = 10) adjusting for relevant confounders

From: Environmental enrichment intervention for Rett syndrome: an individually randomised stepped wedge trial

Outcomes

Coefficient (95%CI)

P value

Coefficient (95%CI)

P value

Coefficient (95%CI)

P value

 

Univariable model (n = 12)

Multivariable model – 1 (n = 12)

Multivariable model – 2 (n = 10)

RSGMS

 Treatment after 2 months

2.7 (0.8, 4.6)

0.01

3.4 (1.5, 5.3)

0.001

  

 Treatment after 4 months

4.6 (2.2, 7.0)

< 0.001

5.7 (3.3, 8.2)

< 0.001

  

 Treatment after 6 months

6.6 (3.7, 9.5)

< 0.001

8.2 (5.1, 11.2)

< 0.001

10.29 (3.20, 17.38)

0.004

 Age (year)

1.0 (−3.1, 5.2)

0.63

−1.6 (−6.0, 2.9)

0.492

−0.12 (−4.70, 4.47)

0.960

 Age at regression (month)

  

1.1 (0.1, 2.2)

0.028

1.06 (0.07, 2.05)

0.035

 Blood BDNF (time-varying)

    

−0.01 (−0.03, 0.01)

0.412

 

Univariable model (n = 10)

Multivariable model (n = 10)

 

Blood BDNF

 Treatment after 6 months

342.9 (297.0, 388.8)

< 0.001

321.4 (272.0, 370.8)

< 0.001

  

 Age (year)

30.1 (10.7, 49.5)

0.002

39.0 (15.6, 62.4)

0.001

  

 Age at regression (month)

  

−4.8 (−10.4, 0.9)

0.098

  

 RSGMS (time-varying)

  

2.4 (−0.6, 5.4)

0.119

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