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Table 1 Mitochondrial complex activities at baseline, pre-training and post-training in Huntington disease (HD) patients and healthy controls

From: Effects of endurance training on skeletal muscle mitochondrial function in Huntington disease patients

 

HD (n = 13)

Controls (n = 11)

 

Baseline

Pre-Training

Post-Training

Pre-Training

Post-Training

Absolute values

 Citrate synthase (mU·mU−1 Protein)

150 ± 42

141 ± 34

163 ± 47##, †

164 ± 65

198 ± 67##, †

 Complex I (mU·mU−1 Protein)

35 ± 11

28 ± 9*

26 ± 7

36 ± 15

33 ± 13

 Complex II (mU·mU−1 Protein)

40 ± 9

38 ± 11

37 ± 11

37 ± 14

44 ± 16

 Complex III (mU·mU−1 Protein)

123 ± 35

114 ± 32

137 ± 51##

122 ± 46

154 ± 55##

 Complex IV (mU·mU−1 Protein)

165 ± 39

151 ± 56

131 ± 47

142 ± 50

164 ± 51

 Complex V (mU·mU−1 Protein)

75 ± 25

72 ± 24

91 ± 29#

69 ± 29

80 ± 26#

 SCCR (mU·mU−1 Protein)

34 ± 11

35 ± 8

49 ± 25##

35 ± 14

46 ± 14##

 NCCR (mU·mU−1 Protein)

28 ± 15

29 ± 12

35 ± 13

26 ± 11

30 ± 10

Relative values

 Complex I (mU·mU−1 CS)

0.241 ± 0.044

0.201 ± 0.051*

0.164 ± 0.037###

0.225 ± 0.049

0.168 ± 0.044###

 Complex II (mU·mU−1 CS)

0.271 ± 0.041

0.269 ± 0.059

0.227 ± 0.038#

0.232 ± 0.044

0.225 ± 0.043#

 Complex III (mU·mU−1 CS)

0.837 ± 0.158

0.828 ± 0.203

0.846 ± 0.184

0.796 ± 0.087

0.779 ± 0.099

 Complex IV (mU·mU−1 CS)

1.124 ± 0.191

1.067 ± 0.300

0.835 ± 0.246

0.871 ± 0.119

0.840 ± 0.133

 Complex V (mU·mU−1 CS)

0.507 ± 0.155

0.522 ± 0.168

0.528 ± 0.109

0.414 ± 0.074

0.400 ± 0.067

 SCCR (mU·mU−1 CS)

0.228 ± 0.056

0.253 ± 0.048

0.269 ± 0.095

0.215 ± 0.033

0.236 ± 0.034

 NCCR (mU·mU−1 CS)

0.185 ± 0.094

0.209 ± 0.081

0.222 ± 0.120††

0.145 ± 0.029

0.153 ± 0.016††

  1. Values are mean ± SD. NCCR, NADH cytochrome c reductase, SCCR, succinate cytochrome c reductase. *P < 0.05, significant different to baseline; # P < 0.05, ## P < 0.01, ### P < 0.001, significant time effect; P < 0.05, P < 0.01, significant group effect