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Table 1 Mitochondrial complex activities at baseline, pre-training and post-training in Huntington disease (HD) patients and healthy controls

From: Effects of endurance training on skeletal muscle mitochondrial function in Huntington disease patients

  HD (n = 13) Controls (n = 11)
  Baseline Pre-Training Post-Training Pre-Training Post-Training
Absolute values
 Citrate synthase (mU·mU−1 Protein) 150 ± 42 141 ± 34 163 ± 47##, † 164 ± 65 198 ± 67##, †
 Complex I (mU·mU−1 Protein) 35 ± 11 28 ± 9* 26 ± 7 36 ± 15 33 ± 13
 Complex II (mU·mU−1 Protein) 40 ± 9 38 ± 11 37 ± 11 37 ± 14 44 ± 16
 Complex III (mU·mU−1 Protein) 123 ± 35 114 ± 32 137 ± 51## 122 ± 46 154 ± 55##
 Complex IV (mU·mU−1 Protein) 165 ± 39 151 ± 56 131 ± 47 142 ± 50 164 ± 51
 Complex V (mU·mU−1 Protein) 75 ± 25 72 ± 24 91 ± 29# 69 ± 29 80 ± 26#
 SCCR (mU·mU−1 Protein) 34 ± 11 35 ± 8 49 ± 25## 35 ± 14 46 ± 14##
 NCCR (mU·mU−1 Protein) 28 ± 15 29 ± 12 35 ± 13 26 ± 11 30 ± 10
Relative values
 Complex I (mU·mU−1 CS) 0.241 ± 0.044 0.201 ± 0.051* 0.164 ± 0.037### 0.225 ± 0.049 0.168 ± 0.044###
 Complex II (mU·mU−1 CS) 0.271 ± 0.041 0.269 ± 0.059 0.227 ± 0.038# 0.232 ± 0.044 0.225 ± 0.043#
 Complex III (mU·mU−1 CS) 0.837 ± 0.158 0.828 ± 0.203 0.846 ± 0.184 0.796 ± 0.087 0.779 ± 0.099
 Complex IV (mU·mU−1 CS) 1.124 ± 0.191 1.067 ± 0.300 0.835 ± 0.246 0.871 ± 0.119 0.840 ± 0.133
 Complex V (mU·mU−1 CS) 0.507 ± 0.155 0.522 ± 0.168 0.528 ± 0.109 0.414 ± 0.074 0.400 ± 0.067
 SCCR (mU·mU−1 CS) 0.228 ± 0.056 0.253 ± 0.048 0.269 ± 0.095 0.215 ± 0.033 0.236 ± 0.034
 NCCR (mU·mU−1 CS) 0.185 ± 0.094 0.209 ± 0.081 0.222 ± 0.120†† 0.145 ± 0.029 0.153 ± 0.016††
  1. Values are mean ± SD. NCCR, NADH cytochrome c reductase, SCCR, succinate cytochrome c reductase. *P < 0.05, significant different to baseline; # P < 0.05, ## P < 0.01, ### P < 0.001, significant time effect; P < 0.05, P < 0.01, significant group effect