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Fig. 1 | Orphanet Journal of Rare Diseases

Fig. 1

From: Morphoproteomics and biomedical analytics coincide with clinical outcomes in supporting a constant but variable role for the mTOR pathway in the biology of congenital hyperinsulinism of infancy

Fig. 1

Pancreas of infant with CHI and paternal ABCC8 showing nucleomegaly (arrows) in islet cells, with insulin production (Frames a, H&E and b, beta cells with insulin), p-mTOR (Ser 2448) on the plasmalemmal aspect of the acinar cells and positivity in the islet cells with nucleomegaly (Frames c and d), p-Akt (Ser 473), expression in the islet cells with nucleomegaly (Frame e) and contrastively, the negative control (Frame f) (Original magnifications frames a-d and F ×400 and ×600 for frame e)

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172