|
Number of patients
|
46
|
16
|
29
|
|
Age at 1st visit (months)
|
|
Median
|
28
|
19
|
30
|
|
Range
|
2 – 171
|
6 – 39
|
2 – 171
|
|
Specialism of 1st referral
|
Nr.
|
%
|
Nr.
|
%
|
Nr.
|
%
|
|
Ear, nose, and throat specialist
|
30
|
65%
|
13
|
81%
|
16
|
55%
|
|
General pediatrician
|
7
|
15%
|
1
|
6%
|
6
|
21%
|
|
Pediatric neurologist
|
2
|
4%
|
0
|
0%
|
2
|
7%
|
|
Pediatric surgeon
|
4
|
9%
|
2
|
13%
|
2
|
7%
|
|
Pediatric cardiologist
|
1
|
2%
|
0
|
0%
|
1
|
3%
|
|
Pediatric psychiatrist
|
2
|
4%
|
0
|
0%
|
2
|
7%
|
|
Symptom leading to 1st referral
|
Nr.
|
%
|
Nr.
|
%
|
Nr.
|
%
|
|
Developmental delay
|
7
|
15%
|
0
|
0%
|
7
|
24%
|
|
Upper airway problems
|
2
|
4%
|
1
|
6%
|
1
|
3%
|
|
Adenotonsillectomy/tympanostomy tubes
|
29
|
63%
|
13
|
81%
|
15
|
52%
|
|
Diarrhea
|
1
|
2%
|
0
|
0%
|
1
|
3%
|
|
Liver problems
|
1
|
2%
|
0
|
0%
|
1
|
3%
|
|
Seizures
|
1
|
2%
|
0
|
0%
|
1
|
3%
|
|
Correction Inguinal/umbilical hernia
|
4
|
9%
|
2
|
13%
|
2
|
7%
|
|
Cardiac murmur
|
1
|
2%
|
0
|
0%
|
1
|
3%
|
|
Other MPS III-related symptoms at 1st referral
|
Nr.
|
%
|
Nr.
|
%
|
Nr.
|
%
|
|
Developmental delay
|
21
|
46%
|
10
|
63%
|
10
|
34%
|
|
Behavioral problems
|
35
|
76%
|
14
|
88%
|
20
|
69%
|
|
Dysmorphic features
|
29
|
63%
|
11
|
69%
|
17
|
59%
|
|
Upper airway problems
|
10
|
22%
|
1
|
6%
|
9
|
31%
|
|
Diarrhea
|
23
|
50%
|
11
|
69%
|
11
|
38%
|
|
Sleeping disturbances
|
21
|
46%
|
9
|
56%
|
12
|
41%
|
|
Inguinal/umbilical hernia
|
11
|
24%
|
9
|
56%
|
2
|
7%
|
