SAD | MAD | |||||
---|---|---|---|---|---|---|
Group I (N = 7)a | Group II (N = 7)a | Group III 100 mg BID (N = 4) | Group IV 200 mg BID (N = 4) | Group V 400 mg BID (N = 4) | Placebo (N = 6) | |
Age (years) | ||||||
Mean (SD) | 30.4 (10.5) | 32.0 (11.3) | 40.8 (13.0) | 34.5 (11.6) | 44.0 (8.2) | 44.7 (9.8) |
Median | 28.0 | 31.0 | 44.0 | 35.0 | 43.0 | 48.5 |
Range | (22–52) | (18–45) | (24–51) | (23–45) | (37–53) | (28–54) |
Height (cm) at screening | ||||||
Mean (SD) | 178.07 (6.56) | 176.01 (8.11) | 184.63 (2.81) | 181.75 (5.25) | 175.70 (3.18) | 175.55 (8.25) |
Median | 177.50 | 177.00 | 184.90 | 183.75 | 176.70 | 171.60 |
Range | (165.7–184.5) | (163.0–187.5) | (181.5–187.2) | (174.0–185.5) | (171.1–178.3) | (170.4–191.5) |
Weight (kg) at screening | ||||||
Mean (SD) | 82.86 (10.56) | 74.29 (12.61) | 89.05 (11.84) | 77.85 (11.96) | 81.10 (4.82) | 72.03 (6.06) |
Median | 80.00 | 78.60 | 89.30 | 80.30 | 82.80 | 72.30 |
Range | (69.8–100.0) | (55.2–88.6) | (77.2–100.4) | (61.2–89.6) | (74.2–84.6) | (62.6–78.8) |
BMI (kg/m2) at screening | ||||||
Mean (SD) | 26.09 (2.51) | 24.01 (4.01) | 26.10 (2.74) | 23.60 (3.82) | 26.28 (1.67) | 23.43 (1.98) |
Median | 26.10 | 22.80 | 26.25 | 24.90 | 26.70 | 23.50 |
Range | (22.5–29.4) | (19.0–29.6) | (23.1–28.8) | (18.2–26.4) | (23.9–27.8) | (21.2–26.6) |
Race | ||||||
White | 7 (100.0%) | 7 (100.0%) | 4 (100.0%) | 4 (100.0%) | 4 (100.0%) | 6 (100.0%) |