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Fig. 1 | Orphanet Journal of Rare Diseases

Fig. 1

From: KH176 under development for rare mitochondrial disease: a first in man randomized controlled clinical trial in healthy male volunteers

Fig. 1

Study design. a. SAD study. D = Dose; SD = Single dose; FU = follow-up. * Each dose was followed by an interim safety and 24-h PK evaluation, which determined the dose selection for the next dose. A washout period of at least 4 days had to be taken into account. b. MAD study. Gr = group; D = Dose; FU = follow-up * Each dose was followed by an interim 7-days safety and PK evaluation, which determined the dose selection for the next dose

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