Fig. 3

Change in left ventricular mass index (LVMI). a Absolute change from baseline^a in LVMI in patients with data available after 1, 2 or 3 years of treatment with idursulfase. b Percentage change from baseline in LVMI in patients with data available after 1, 2 or 3 years of treatment with idursulfase. Box plots illustrate the 25th, 50th (median) and 75th percentiles (boxes) and the 10th and 90th percentiles (whiskers). ^aThe baseline measurement was defined as the last recorded measurement in the 12 months preceding the start of idursulfase treatment. A post-baseline measurement was defined as the value recorded closest to the 1st, 2nd or 3rd anniversary of the baseline measurement, within 6 months either side of the anniversary date. If there were two values within equal times of the evaluation visit, the first value was used