Prevalence and risk factors for type 2 diabetes mellitus with Prader–Willi syndrome: a single center experience

Table 2 Univariate and multivariate logistic regression analyses of variables associated with risk of T2DM in PWS

Variables	Univariate analysis		Multivariate analysis
Variables	OR (95% CI)	P-value^*	OR (95% CI)	P-value^*
Age (>18 years)	6.81 (2.51–18.47)	<.001	1.87 (0.47–7.47)	0.373
Gender (male)	0.38 (0.14–1.04)	0.060	0.60 (0.16–2.28)	0.455
Genotype (deletion)	0.85 (0.30–2.40)	0.756	-	-
Obesity^a (BMI > 2SD or >30 kg/m²)	5.75 (2.02–16.40)	0.001	6.76 (2.10–21.70)	0.001
HOMA-IR	1.31 (1.09–1.59)	0.005	1.73 (1.31–2.29)	<.001
Dyslipidemia (yes)	4.92 (1.84–13.20)	0.002	1.55 (0.38–6.33)	0.545
GHT (yes)	0.39 (0.11–1.37)	0.141	-	-
Age at GHT start (years)	1.02 (0.90–1.15)	0.792	-	-
Duration of GHT (≥7.2 years)	0.75 (0.27–2.07)	0.572	-	-
Hypogonadism (yes)	3.33 (1.30–8.53)	0.012	2.15 (0.61–7.63)	0.237
Central precocious puberty (yes)	0.27 (0.06–1.28)	0.10	-	-

Variables with p < 0.10 were included in a multivariate logistic regression with conditional backward selection model
Abbreviations: T2DM type 2 Diabetes Mellitus, PWS Prader-Willi syndrome, OR odds ratio, CI confidence interval, GHT growth hormone treatment, HOMA-IR homeostasis model assessment, BMI body mass index
^*Significant association was classified as p < 0.05
^aObesity is defined as BMI cut-off point >30 in adults, >2 SDS in children and adolescents

ISSN: 1750-1172