DM, n (%) 29 (34.5) | Non-DM, n (%) 55 (65.5) | Total, n (%) 84 (100) | p-value* | |
---|---|---|---|---|
Age (years) (range) | 20.4 ± 5.7 (12.7–35.8) | 15.8 ± 4.1 (10.3–31.8) | 17.4 ± 5.1 (10.3–35.8) | < 0.001 |
Age at diagnosis with DM (years) | 15.9 ± 3.6 (10.1–27.0) | - | - | - |
Age at diagnosis with PWS (years) | 6.9 ± 7.2 | 4.7 ± 5.0 | 5.5 ± 5.9 | 0.151 |
Gender (male), n (%) | 22 (75.9) | 30 (54.5) | 52 (61.9) | 0.057 |
Genotype (deletion), n (%) | 21 (72.4) | 38 (69.1) | 59 (70.2) | 0.757 |
BMI, kg/m2 (SD) | 35.7 ± 9.2 (2.8 ± 1.0) | 28.3 ± 8.9 (1.7 ± 1.3) | 30.8 ± 9.6 (2.1 ± 1.3) | < 0.001 |
Obesitya, n (%) | 23 (79.3) | 22 (40) | 57 (67.9) | 0.001 |
HOMA-IR | 6.3 ± 3.5 | 3.4 ± 3.8 | 4.4 ± 3.9 | 0.001 |
HbA1C, % (mmol/mol) | 8.4 ± 2.3 | 5.6 ± 0.3 | 6.6 ± 1.9 | < 0.001 |
Basal insulin (μIU/mL) | 45.7 ± 31.1 | 25.3 ± 23.0 | 32.5 ± 27.7 | 0.001 |
Basal C-peptide (ng/mL) | 7.0 ± 2.8 | 4.8 ± 2.9 | 5.7 ± 3.0 | 0.004 |
Age at GHT start (years) | 7.0 ± 3.8 | 6.7 ± 4.3 | 6.8 ± 4.1 | 0.795 |
Previous GHT duration (years) | 6.3 ± 3.3 | 7.5 ± 3.1 | 7.2 ± 3.2 | 0.140 |
GHT, n (%) | 21 (72.4) | 50 (90.9) | 71 (84.5) | 0.027 |
Dyslipidemia, n (%) | 16 (55.2) | 11 (20.0) | 27 (32.1) | 0.001 |
Hypothyroidism, n (%) | 0 (0) | 2 (3.6) | 2 (2.4) | 0.988 |
Hypogonadism, n (%) | 19 (65.5) | 20 (36.4) | 39 (46.4) | 0.011 |
Central precocious puberty, n (%) | 2 (6.9) | 12 (21.8) | 14 (16.7) | 0.071 |