Evaluation of pre-symptomatic nitisinone treatment on long-term outcomes in Tyrosinemia type 1 patients: a systematic review

Table 2 Study quality of included studies according to EPHPP quality assessment tool [16]

Study	Global rating from sections A-F						Global rating for this study
Study	A) Selection bias	B) Study design	C) Confounders	D) Blinding	E) Data collection methods	F) Withdrawals and drop-outs	Global rating for this study
Québec study
Larochelle 2012 [10]	Strong	Moderate	Weak	Moderate	Strong	Strong	Moderate
Simoncelli 2015 [11]	Strong	Moderate	Weak	Moderate	Strong	Strong	Moderate
Birmingham study
Bartlett 2014 [17]	Strong	Moderate	Weak	Moderate	Strong	Strong	Moderate
McKiernan 2015 [14]	Weak	Moderate	Weak	Moderate	Weak	Strong	Weak
Santra 2008 [12]	Moderate	Moderate	Weak	Moderate	Weak	Weak	Weak
International cohort
Mayorandan 2014 [18]	Weak	Moderate	Weak	Moderate	Weak	Strong	Weak
Cross-sectional study
Van Ginkel 2016 [19]	Weak	Weak	Weak	Moderate	Strong	Strong	Weak

ISSN: 1750-1172