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Table 2 Study quality of included studies according to EPHPP quality assessment tool [16]

From: Evaluation of pre-symptomatic nitisinone treatment on long-term outcomes in Tyrosinemia type 1 patients: a systematic review

Study Global rating from sections A-F Global rating for this study
A) Selection bias B) Study design C) Confounders D) Blinding E) Data collection methods F) Withdrawals and drop-outs
Québec study
 Larochelle 2012 [10] Strong Moderate Weak Moderate Strong Strong Moderate
 Simoncelli 2015 [11] Strong Moderate Weak Moderate Strong Strong Moderate
Birmingham study
 Bartlett 2014 [17] Strong Moderate Weak Moderate Strong Strong Moderate
 McKiernan 2015 [14] Weak Moderate Weak Moderate Weak Strong Weak
 Santra 2008 [12] Moderate Moderate Weak Moderate Weak Weak Weak
International cohort
 Mayorandan 2014 [18] Weak Moderate Weak Moderate Weak Strong Weak
Cross-sectional study
 Van Ginkel 2016 [19] Weak Weak Weak Moderate Strong Strong Weak