Skip to main content

Table 9 Reported Phe tolerance during pregnancy in maternal PKU

From: The complete European guidelines on phenylketonuria: diagnosis and treatment

Reference

Number of patients

1st trimester

2nd trimester

3rd trimester

Vockley et al. 2014 [102]

0 (USA guidelines)

265–770 mg/day

400–1650 mg/day

700–2275 mg/day

Acosta et al. 2001 [350]

240

456 ± 233 to 684 ± 413 mg/day

528 ± 269 to 528 ± 269 mg/day

938 ± 542 to 1248 ± 513 mg/day

Thompson et al. 1991 [351]

1

6 mg/kg bodyweight/day

 

30 mg/kg bodyweight/day

Kohlschutter et al. 2009 [343]

3

400 mg/day

 

1700 mg/day (non-foetal PKU)

maximum 600 mg/day (foetal PKU)

Duran et al. 1999 [232]

5

250–500 mg/day

300–500 mg/day

 

Rohr et al. 1987 [369]

3

450–800 mg/day

720–1300 mg/day

1300–1500 mg/day