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Table 9 Reported Phe tolerance during pregnancy in maternal PKU

From: The complete European guidelines on phenylketonuria: diagnosis and treatment

Reference Number of patients 1st trimester 2nd trimester 3rd trimester
Vockley et al. 2014 [102] 0 (USA guidelines) 265–770 mg/day 400–1650 mg/day 700–2275 mg/day
Acosta et al. 2001 [350] 240 456 ± 233 to 684 ± 413 mg/day 528 ± 269 to 528 ± 269 mg/day 938 ± 542 to 1248 ± 513 mg/day
Thompson et al. 1991 [351] 1 6 mg/kg bodyweight/day   30 mg/kg bodyweight/day
Kohlschutter et al. 2009 [343] 3 400 mg/day   1700 mg/day (non-foetal PKU)
maximum 600 mg/day (foetal PKU)
Duran et al. 1999 [232] 5 250–500 mg/day 300–500 mg/day  
Rohr et al. 1987 [369] 3 450–800 mg/day 720–1300 mg/day 1300–1500 mg/day