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Table 5 Evidence supporting free use of fruit and vegetables containing Phe ≤75 mg/100 g

From: The complete European guidelines on phenylketonuria: diagnosis and treatment

Reference N Fruit/veg criteria Study design Change in Phe intake Blood Phe control Grade of evidence
MacDonald et al. 2003 [276] 15 Free use of fruit and veg ≤75 mg/100 g Phe
Not potatoes
15 week systematic challenge Mean Phe # Approx 50 mg/day No impact on Phe control 2−/C
Rohde et al. 2012 [191] 14 Free use of fruit and veg ≤75 mg/100 g Phe 2 week randomised cross-over -trial Mean Phe # Approx 50–60 mg/day No impact on Phe control 1−/B
Rohde et al. 2014 [277] 19 Free use of fruit and veg ≤75 mg/100 g Phe 1 year follow up study Mean Phe # Approx 60–70 mg/day No impact on Phe control 2−/C
Zimmermann et al. 2012 [278] 50 Free use of fruit and veg ≤100 mg/100 g Phe Not potatoes Up to 3 year follow up study Unreported No impact on Phe control 2−/C
  1. N number of patients