Table 5 Evidence supporting free use of fruit and vegetables containing Phe ≤75 mg/100 g
From: The complete European guidelines on phenylketonuria: diagnosis and treatment
Reference | N | Fruit/veg criteria | Study design | Change in Phe intake | Blood Phe control | Grade of evidence |
|---|---|---|---|---|---|---|
MacDonald et al. 2003 [276] | 15 | Free use of fruit and veg ≤75 mg/100 g Phe Not potatoes | 15 week systematic challenge | Mean Phe # Approx 50 mg/day | No impact on Phe control | 2−/C |
Rohde et al. 2012 [191] | 14 | Free use of fruit and veg ≤75 mg/100 g Phe | 2 week randomised cross-over -trial | Mean Phe # Approx 50–60 mg/day | No impact on Phe control | 1−/B |
Rohde et al. 2014 [277] | 19 | Free use of fruit and veg ≤75 mg/100 g Phe | 1 year follow up study | Mean Phe # Approx 60–70 mg/day | No impact on Phe control | 2−/C |
Zimmermann et al. 2012 [278] | 50 | Free use of fruit and veg ≤100 mg/100 g Phe Not potatoes | Up to 3 year follow up study | Unreported | No impact on Phe control | 2−/C |