Table 16 Expected positive outcome changes with Phe-restricted dietary treatment in untreated PKU patients

Behaviour

 Less aggressive behaviour, self-injury, hyperactivity, restlessness, irritability, sleep disorders, anxiety, stereotyped behaviour

 Improved mood change, social interaction, verbal communication, daily living skills

Neurology

 Improvement of attention span, alertness, short-term memory processes, motor skills, seizures, spasticity, tremors

Other clinical parameters

 Improvement/disappearance of eczema, skin rash, body odour Darker hair colour

Quality of life

 Reduced nursing time

Medication

 e.g. less use of sedative, anti-psychotic, anticonvulsants