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Table 12 Reported Tyr supplementation during pregnancy in maternal PKU

From: The complete European guidelines on phenylketonuria: diagnosis and treatment

Author Tyr supplementation
Coutts 1979 [358] >10 g/day
Singh et al. 2014 [361], Vockley et al. 2014 [102] 6000 to 7600 mg/day
Rohr et al. 1987 [369] Up to 6 g/d (did not ↑ blood Tyr >30 μmol/l)
Davidson et al. 1989 [364] 6.4–11.9 g/day
Brenton et al. 1996 [363] 2 g/day
Maillot et al. 2007 [333] 8 g/day (total from Phe-free L-amino acid supplements and Tyr supplements)
Thompson et al. 1991 [351] 160 mg/kg/day- starting point and then titrate according to Tyr levels