Table 3 Surface accessibility of native and mutant IDUA variants that are selected for structural analysis
From: Phenotype prediction for mucopolysaccharidosis type I by in silico analysis
SNP ID | AA | AA position | RSA | ASA | Z-fit score for RSA prediction | Class assignment |
|---|---|---|---|---|---|---|
rs121965021 | P | 533 | 0.341 | 48.43 | −1.149 | Buried |
R | 0.344 | 78.73 | −0.651 | Buried | ||
rs371397270 | D | 349 | 0.241 | 34.699 | −0.488 | Buried |
G | 0.392 | 30.819 | −1.405 | Exposed | ||
rs775816150 | T | 374 | 0.095 | 13.149 | −1.852 | Buried |
P | 0.233 | 33.134 | −1.134 | Buried | ||
rs772416503 | P | 496 | 0.105 | 14.928 | 0.247 | Buried |
R | 0.164 | 37.533 | −0.253 | Buried | ||
rs121965033 | L | 346 | 0.031 | 5.603 | 0.342 | Buried |
R | 0.108 | 24.09 | −0.954 | Buried |