|
Author
|
Data range
|
Country
|
Design
|
TINU cases/ population(n)
|
TINU cases (%)
|
|---|
|
‘All-age’ Studies with >500 patients
|
|
Rodriguez [47]
|
1982–1992
|
USA
|
Retrospective
|
0/1237
|
0
|
|
Rothova [48]
|
1984–1989
|
The Netherlands
|
Retrospective
|
0/865
|
0
|
|
Mackensen [7]*
|
1985–2005
|
USA
|
Retrospective
|
33/1985
|
1.66
|
|
Mercanti [49]
|
1986–1993
|
Italy
|
Retrospective
|
0/655
|
0
|
|
Oruc [50]
|
1990–1995
|
USA
|
Retrospective
|
0/853
|
0
|
|
Tran [51]
|
1990–1993
|
Switzerland
|
Prospective
|
0/558
|
0
|
|
Jones [9]
|
1991–2013
|
UK
|
Prospective
|
7/3000
|
0.23
|
|
Kotake [52]
|
1994
|
Japan
|
Retrospective
|
4/551
|
0.73
|
|
Barisani-Asenbauer [53]
|
1995–2009
|
Austria
|
Retrospective
|
0/2619
|
0
|
|
Rathinam [54]
|
1996–2001
|
India
|
Retrospective
|
0/8759
|
0
|
|
Singh [55]
|
1996–2001
|
India
|
Retrospective
|
0/1233
|
0
|
|
Yang [56]
|
1996–2003
|
China
|
Retrospective
|
0/1752
|
0
|
|
Soheilian [57]
|
1997–2000
|
Iran
|
Retrospective
|
0/544
|
0
|
|
Jakob [12]
|
2001–2006
|
Germany
|
Retrospective
|
10/1916
|
0.52
|
|
Al Dhibi [58]
|
2001–2010
|
Saudi Arabia
|
Retrospective
|
0/888
|
0
|
|
Kazokoglu [59]
|
2004
|
Turkey
|
Prospective
|
0/761
|
0
|
|
Ohguro [8]
|
2009–2010
|
Japan
|
Prospective
|
15/3830
|
0.39
|
|
Gonzalez Fernandez [60]
|
2012–2013
|
Brazil
|
Prospective
|
0/1053
|
0
|
|
Total
| | | |
69/33059
|
0.21
|
|
Paediatric Studies with >250 patients
|
|
Smith [61]
|
1980–2005
|
USA
|
Retrospective
|
12/527
|
2.28
|
|
Kump [4]
|
1985–2003
|
USA
|
Retrospective
|
3/269
|
1.12
|
|
BenEzra [62]
|
1989–1999
|
Israel
|
Retrospective
|
4/275
|
1.45
|
|
Paroli [63]
|
1995–2004
|
Italy
|
Retrospective
|
4/257
|
1.55
|
|
Total
| | | |
23/1328
|
1.73
|
- For inclusion a minimum number of 500 was required for ‘all age’ cohorts and a minimum number of 250 patients for paediatric cohorts. As discussed in the text, it should be recognised that studies which report 0 cases of TINU may do so due to (1) a true rarity in that population, (2) non-reporting of diagnosed cases (eg studies marked with a ‘+’ include the listing of ‘other diagnoses’ which could potentially include TINU cases), or (3) underdiagnosis
- *Includes ‘possible’ as well as ‘probable’ and ‘definite’ cases
