Prevalence, incidence and carrier frequency of 5q–linked spinal muscular atrophy – a literature review

Table 5 SMN1 allele frequencies per ethnicity

	Frequency by number of SMN1 copies on a single allele
	0 Copies		1 Copy		2 Copies
Ethnicity^a	Portion	95% CI	Portion	95% CI	Portion	95% CI
Asian	0.010	0.010–0.011	0.949	0.948–0.950	0.040	0.039–0.041
Asian Indian^b	0.010	0.006–0.015	0.908	0.894–0.921	0.082	0.070–0.095
Black (Sub-Saharan ancestry)	0.007	0.005–0.009	0.717	0.708–0.725	0.276	0.268–0.285
Caucasian	0.011	0.010–0.012	0.954	0.952–0.955	0.035	0.034–0.037
Hispanic	0.007	0.006–0.008	0.915	0.911–0.919	0.078	0.074–0.082
Jewish	0.010	0.009–0.011	0.934	0.931–0.936	0.057	0.054–0.059

Median and 95% posterior intervals of copy number allele frequency, based on studies presented in Additional file 3
CI confidence interval
^a) Same ethnicities as in Table 4 are included
^b) Only consists of one study

ISSN: 1750-1172