Fig. 2
From: ATM splicing variants as biomarkers for low dose dexamethasone treatment of A-T
ATMdexa1 expression in responders and non-responders. In panel a, AT patients treated with EryDex were divided into two clusters (responders R n = 5 and non-responders NR n = 5, by average ICARS value decrement of at least 10 points, after six months of therapy). Responders showed higher levels of ATMdexa1 expression (p < 0.05) than did non-responders. In panel b, for one patient from each cluster, it was possible to evaluate the expression of ATMdexa1 also at +8 days from EryDex administration. In both cases, the extent of the target expression was time dependent