Fig. 3
From: Prenatal brain disruption in isolated sulfite oxidase deficiency
Brain MRI of the ISOD fetus and the normal control images of brain development at gestational age 21 weeks. a and b, Axial brain images (TE 93 ms, TR 1400 ms, Matrix 256 × 166, FOV 200 nm, Slice 3 mm, Voxel size 0.98 × 0.78 × 3 mm3) of the ISOD fetus at gestational age 21 weeks show poor gyration at left sylvian fissure (arrow) (a) and right lateral sulcus (arrow head), and poor differentiation of the cortical layers (a and b). c and d, Axial brain images (TE 96 ms, TR 1400 ms, Matrix 256 × 166, FOV 200 nm, Slice 3 mm, Voxel size 0.98 × 0.78 × 3 mm3) of the normal control at gestational age 21 weeks show normal gyration at the sylvian fissure (c) and lateral sulcus (d). Normal 5 layered appearance of the brain cortex, from medial to lateral, shows ventricular zone/ germinal matrix (red arrow), periventricular zone (yellow arrow), intermediate zone (green arrow), subplate (blue arrow), and cortical zone (pink arrow) (d). This finding indicates that neurodevelopment is affected early in the prenatal stage