Table 3 Odds ratio (OR) estimates for Hirschsprung’s Disease from logistic regression models, crude and adjusted OR with 95% confidence interval (CI) for occurrence of Hirschsprung’s Disease based on all live births in the period of 1 january 1996 until 12 March 2016. All women with prescriptions 3 months prior to time of conception of antiepileptic, antidiabetic, antipsychotics, anxiolytic and tricyclic antidepressants are excluded from the population

Child born with Hirschsprung’s Disease

13/16.395 (0.08%)

561/1.207.989 (0.05%)

1.71 (0.99–2.96)

1.76 (1.01–3.07)

SSRI prescriptions redeemed one time only

No prescriptions for SSRIs

Crude OR (95%CI)

Adjusted OR^a (95%CI)

Child born with Hirschsprung’s Disease

6/9.663 (0.06%)

561/1.207.989 (0.05%)

1.34 (0.60–3.00)

1.38 (0.61–3.09)

SSRI prescriptions redeemed a minimum of two times

No prescriptions for SSRIs

Crude OR (95%CI)

Adjusted OR^a (95%CI)

Child born with Hirschsprung’s Disease

7/6.732 (0.10%)

561/1.207.989 (0.05%)

2.24 (1.06–4.72)

2.32 (1.10–4.90)