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Table 3 Odds ratio (OR) estimates for Hirschsprung’s Disease from logistic regression models, crude and adjusted OR with 95% confidence interval (CI) for occurrence of Hirschsprung’s Disease based on all live births in the period of 1 january 1996 until 12 March 2016. All women with prescriptions 3 months prior to time of conception of antiepileptic, antidiabetic, antipsychotics, anxiolytic and tricyclic antidepressants are excluded from the population

From: Maternal use of selective serotonin reuptake inhibitors during pregnancy is associated with Hirschsprung’s disease in newborns – a nationwide cohort study

  SSRI prescriptions redeemed a minimum of one time No prescriptions for SSRIs Crude OR (95%CI) Adjusted ORa (95%CI)
Child born with Hirschsprung’s Disease 13/16.395 (0.08%) 561/1.207.989 (0.05%) 1.71 (0.99–2.96) 1.76 (1.01–3.07)
  SSRI prescriptions redeemed one time only No prescriptions for SSRIs Crude OR (95%CI) Adjusted ORa (95%CI)
Child born with Hirschsprung’s Disease 6/9.663 (0.06%) 561/1.207.989 (0.05%) 1.34 (0.60–3.00) 1.38 (0.61–3.09)
  SSRI prescriptions redeemed a minimum of two times No prescriptions for SSRIs Crude OR (95%CI) Adjusted ORa (95%CI)
Child born with Hirschsprung’s Disease 7/6.732 (0.10%) 561/1.207.989 (0.05%) 2.24 (1.06–4.72) 2.32 (1.10–4.90)
  1. aAdjusted for maternal age (≤19, 20–24, 25–29, 30–34, ≥35), maternal smoking (yes/no), sex, of child (male/female), parity (1/<1), calendar year of birth (1996–2001, 2002–2007, 2008–2011, 2012–2016)